Multiple Sclerosis Research Today is a free monthly online journal that collates and summarizes the latest research about Multiple Sclerosis, including details on diagnosis, symptoms, treatment, prognosis.

Multiple sclerosis: novel perspectives on newly forming lesions.

Matute C, Pérez-Cerdá F

Departamento de Neurociencias, Universidad del País Vasco, E-48940 Leioa, Vizcaya, Spain. onpmaalc@lg.ehu.es

The mechanisms underlying lesion formation in multiple sclerosis are unknown. The prevailing view is that macrophages are primary mediators of myelin destruction in the relapsing and remitting forms of this disease. However, recent findings have revealed widespread oligodendrocyte apoptosis in the absence of a clear cellular immune response. These observations unveil a novel aspect of the pathogenesis of multiple sclerosis that is worthy of further exploration.

Published 5 April 2005 in Trends Neurosci, 28(4): 173-5.
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