Multiple Sclerosis Research Today is a free monthly online journal that collates and summarizes the latest research about Multiple Sclerosis, including details on diagnosis, symptoms, treatment, prognosis.

Spinal and cranial hypertrophic neuropathy in multiple sclerosis.

Quan D, Pelak V, Tanabe J, Durairaj V, Kleinschmidt-Demasters BK

Department of Neurology, University of Colorado Health Sciences Center, Box F727, 4200 East Ninth Avenue, Denver, Colorado 80262, USA. dianna.quan@uchsc.edu

Two patients with multiple sclerosis developed symptomatic chronic inflammatory demyelinating polyneuropathy with massive spinal or cranial nerve hypertrophy revealed by neuroimaging. Sural nerve biopsy in one showed only moderate demyelination, axonal loss, and onion-bulb formation, illustrating dichotomy between severe proximal and milder distal nerve involvement. Patients with coexistent central and peripheral demyelination usually are symptomatic from dysfunction at one site or the other, but not from both. Our patients showed minimal response to steroids, intravenous immunoglobulin, or azathioprine. These cases suggest that the mechanism of disease in symptomatic central and peripheral demyelination may differ from that of disease in only one region, and that optimal therapy in this situation must be explored further.

Published 6 June 2005 in Muscle Nerve, 31(6): 772-9.
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