Multiple Sclerosis Research Today is a free monthly online journal that collates and summarizes the latest research about Multiple Sclerosis, including details on diagnosis, symptoms, treatment, prognosis.

E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis.

Galimberti D, Fenoglio C, Clerici R, Comi C, De Riz M, Rottoli M, Piccio L, Ronzoni M, Venturelli E, Monaco F, Poloni M, Bresolin N, Scarpini E

Department of Neurological Sciences, "Dino Ferrari" Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy. daniela.galimbert@unimi.it

Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.

Published 11 July 2005 in J Neuroimmunol, 165(1): 201-5.
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